In-silico ADMET profile of Ellagic Acid from Syzygium cumini: A Natural Biaryl Polyphenol with Therapeutic Potential to Overcome Diabetic Associated Vascular Complications

Plant Based Natural Products (PBNPs) are the primary source of natural antioxidants capable neutralizing or eliminating harmful Reactive Oxygen Species (ROS). Oxidative stress contributes not only to pathogenesis type 2 diabetes (T2DM) but also diabetic related vascular complications by lipid peroxidation. Oxidation induced DNA and protein damage leads development like coronary heart disease, CVD, stroke, neuropathy, retinopathy, nephropathy, CKD, other long term associated with diabetics. Likewise Multidrug resistance (MDR) is one major clinical challenges in cancer treatment compromises effectiveness conventional anticancer chemotherapeutics. P-glycoprotein (P-gp) has been characterized as a mechanism MDR. Ellagic acid (EA) bioactive secondary metabolite widely distributed vegetables fruits (Strawberry, Grapes, Blackberry, Raspberry, Plums etc.) Chemically, EA 2,3,7,8-tetrahydroxychromeno [5,4, -cde] chromene-5, 10-dione, heterotetracyclic dimer Gallic Acid (GA) molecules formed oxidative aromatic coupling involving intramolecular lactonization. pharmacological activities such anti-inflammatory, neuroprotective, cardio-protective, antioxidant, anti-mutagenic, multidrug etc. marketed dietary supplement claimed benefits against cancer, CKD metabolic disorders. However, limitation attributed its low solubility water reduced bioavailability. In present study, bimolecular potential bioprospected revised framework ADMET pharmacoinformatics further widen biomedical applications.
 Keywords: ADMET; Pharmacoinformatics; Acid; Syzygium cumini; Alagarkovil Reserve Forest (ARF); (ROS)